During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Mechanosensation is perhaps the last sensory modality not understood at the molecular
level. Ion channels that sense mechanical force are postulated to play critical roles in a …

Most cellular processes are carried out by multiprotein complexes. The identification and
analysis of their components provides insight into how the ensemble of expressed proteins …

Tissue macrophages provide immunological defense and contribute to the establishment
and maintenance of tissue homeostasis. Here we used constitutive and inducible …

The ADAMs family of transmembrane proteins belongs to the zinc protease superfamily.
Members of the family have a modular design, characterized by the presence of …

▪ Abstract Mouse embryonic stem cells are continuous cell lines derived directly from the
fetal founder tissue of the preimplantation embryo. They can be expanded in culture while …

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored
metalloproteases that process and shed the ectodomains of membrane-anchored growth …

Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous
system. Here we review the evidence that supports this idea and discuss the possible …

One of the most effective approaches for determining gene function involves engineering
mice with mutations or deletions in endogenous genes of interest. Historically, this approach …