The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

The neocortex is a complex neurobiological system with many interacting regions. How
these regions work together to subserve flexible behavior and cognition has become …

Elucidating the cellular organization of the cerebral cortex is critical for understanding brain
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …

Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …

Neural processing occurs across a range of temporal scales. To facilitate this, the brain uses
fast-changing representations reflecting momentary sensory input alongside more …

Cortical circuits are thought to contain a large number of cell types that coordinate to
produce behavior. Current in vivo methods rely on clustering of specified features of …

Neurons in the association cortices are particularly vulnerable in cognitive disorders such as
schizophrenia and Alzheimer's disease, while those in primary visual cortex remain …

In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical
layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To …

Ketamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-
acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes …

Voluntary attention selects behaviorally relevant signals for further processing while filtering
out distracter signals. Neural correlates of voluntary visual attention have been reported …