Metastatic breast, prostate, lung, and other cancers often affect bone, causing pain,
increasing fracture risk, and decreasing function. Management of metastatic bone disease …

Simple Summary Major progress has been achieved in stage-IV bone metastatic patients to
control over the disease progression, thereby resulting in longer survival. Self-autonomy and …

The objective of this study was to develop a new calibration method that enables calibration
of Hounsfield units (HU) to bone mineral densities (BMD) without the use of a calibration …

Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone
disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which …

Purpose To determine whether patient-specific finite element (FE) computer models are
better at assessing fracture risk for femoral bone metastases compared to clinical …

Objectives In this prospective cohort study, we investigated whether patient-specific finite
element (FE) models can identify patients at risk of a pathological femoral fracture resulting …

Background Predicting patient specific risk of fracture in femurs with metastatic tumors and
the need for surgical intervention are of major clinical importance. Recent patient-specific …

There is an urgent need to improve the prediction of fracture risk for cancer patients with
bone metastases. Pathological fractures that result from these tumors frequently occur in the …

Denosumab reduced the incidence of new fractures in postmenopausal women with
osteoporosis by 68% at the spine and 40% at the hip over 36 months compared with …

Predicting fracture risk for patients with metastatic femoral lesions remains an important
clinical problem. Mirels' criterion remains the most formalized radiographic scoring system …