ABSTRACT Introduction: Human adenovirus (HAdV)-derived vectors have been used in
numerous pre-clinical and clinical trials during the last 40 years. Current research in HAdV …

In the progression of the life cycle of Plasmodium falciparum, a small proportion of asexual
parasites differentiate into male or female sexual forms called gametocytes. Just like their …

Background Transmission blocking vaccines targeting the sexual-stages of the malaria
parasite could play a major role to achieve elimination and eradication of malaria. The …

Abstract The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-
blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit …

Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

Transmission-blocking vaccines have the potential to be key contributors to malaria
elimination. Such vaccines elicit antibodies that inhibit parasites during their development in …

Plasmodium vivax (P. vivax) is the major malaria parasite outside of Africa and no vaccine is
available against it. A vaccine that interrupts parasite transmission (transmission-blocking …

Plasmodium falciparum transmission-blocking vaccines (TBVs) targeting the Pfs25 antigen
have shown promise in mice but the same efficacy has never been achieved in humans. We …

Background Leading transmission-blocking vaccine candidates such as Plasmodium
falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may …

Acknowledging the fallibilities of recalling events from more than three decades ago, the
recollection of Richard Carter's impact on the identification and development of Pfs25, a …