Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant …

There has been confusion as to what role (s) nitric oxide (NO) has in different physiological
and pathophysiological mechanisms. Some studies imply that NO has cytotoxic properties …

During apoptosis, mitochondrial membrane permeability (MMP) increases and the release
into the cytosol of pro-apoptotic factors (procaspases, caspase activators and caspase …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Forkhead transcription factors of the FOXO class are negatively regulated by PKB/c‐Akt in
response to insulin/IGF signalling, and are involved in regulating cell cycle progression and …

Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-κB/IκB) complex leading to its
activation, NF-κB translocation into the nucleus, DNA binding, and transactivation have been …

The roles of nitric oxide (NO) in numerous disease states have generated considerable
discussion over the past several years. NO has been labeled as the causative agent in …

Nuclear factor-κB (NFκB) is a transcription factor with a pivotal role in inducing genes
involved in physiological processes as well as in the response to injury and infection. A …