Mechanisms and regulation of endothelial VEGF receptor signalling
M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …
required to balance the formation of new blood vessels with the maintenance and …
The front and rear of collective cell migration
R Mayor, S Etienne-Manneville - Nature reviews Molecular cell biology, 2016 - nature.com
Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …
RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
VEGF targets the tumour cell
HL Goel, AM Mercurio - Nature Reviews Cancer, 2013 - nature.com
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …
Integrins in cancer: biological implications and therapeutic opportunities
JS Desgrosellier, DA Cheresh - Nature Reviews Cancer, 2010 - nature.com
The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …
crucial to the initiation, progression and metastasis of solid tumours. The importance of …
[HTML][HTML] Integrins as attractive targets for cancer therapeutics
M Li, Y Wang, M Li, X Wu, S Setrerrahmane… - … Pharmaceutica Sinica B, 2021 - Elsevier
Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …
human physiological and pathological processes. These molecules facilitate cell …
[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities
F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate the interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …
extracellular matrix (ECM) and cells and are essential for cell migration and the …
Vascular endothelial growth factor: basic science and clinical progress
N Ferrara - Endocrine reviews, 2004 - academic.oup.com
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …
Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances
S Xu, BZ Olenyuk, CT Okamoto… - Advanced drug delivery …, 2013 - Elsevier
Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …
Endothelial cell migration during angiogenesis
Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …