Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Fast-spiking, inhibitory interneurons–prototype is the parvalbumin-positive (PV+) basket cell–
generate action potentials at high frequency and synchronize the activity of numerous …

Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than
the disease and are ineffective in up to 30% of patients. There are no treatments for …

Hypometabolism, characterized by decreased brain glucose consumption, is a common
feature of many neurodegenerative diseases. Initial hypometabolic brain state, created by …

Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition
imbalance from a neuro-centric view. Although astrocyte-neuron interactions are …

Seizures are often the key manifestation of neurological diseases caused by pathogenic
mutations in 169 of the genes that have so far been identified to affect mitochondrial …

An insult to the brain (such as the first seizure) causes excitotoxicity, neuroinflammation, and
production of reactive oxygen/nitrogen species (ROS/RNS). ROS and RNS produced during …

The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

Gamma oscillations (~ 30 to 100 Hz) provide a fundamental mechanism of information
processing during sensory perception, motor behavior, and memory formation by …

Previous studies from our group, focusing on neuro-glial remodelling in human temporal
lobe epilepsy (TLE), have shown the presence of immature vascular cells in various areas of …