Enzymes catalyze a variety of biochemical reactions in the body and, in conjunction with
transporters and receptors, control virtually all physiological processes. There is great value …

Information about the rates of hydrolysis of neuropeptides by extracellular peptidases can
lead to a quantitative understanding of how the steady-state and transient concentrations of …

Pressure-induced infusion of solutions into brain tissue is used both in research and in
medicine. In medicine, convection enhanced delivery (CED) may be used to deliver agents …

On-column focusing is essential for satisfactory performance using capillary scale columns.
On-column focusing results from generating transient conditions at the head of the column …

There are many processes that actively alter the concentrations of solutes in the extracellular
space. Enzymatic reactions, either by soluble enzymes or membrane-bound ectoenzymes …

Background Delivering solutes to a particular region of the brain is currently achieved by
iontophoresis for very small volumes and by diffusion from a microdialysis probe for larger …

Objective: Cerebral edema characterized as an abnormal accumulation of interstitial fluid
has not been treated effectively. We propose a novel edema treatment approach to drive …

It has been known for over a century that the hippocampus, the center for learning and
memory in the brain, is selectively vulnerable to ischemic damage, with the CA1 being more …

This work demonstrates a reduced tip μ-low-flow-push–pull perfusion technique for ex vivo
sampling of the extracellular space of mouse hippocampal brain slices. Concentric fused …

Many sampling methods have been developed to measure the extracellular concentrations
of solutes in the extracellular space of mammalian tissue, eg, brain. However, few have …