Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well
understood. Here, we show that diet-induced obesity (DIO) causes massive remodeling of …

Background Chronobiology is devoted to the study of biological rhythms. It is possible that a
given medication may be therapeutic and safe when administered at some time, but …

Background Evidence about the optimal time of day at which to administer statins is lacking.
Objective The objective of this study is to synthesize evidence about effects of morning vs …

Although much has been learned about circadian clocks and rhythms over the past few
decades, translation of this foundational science underlying the temporal regulation of …

Hyperlipidaemia is a major risk factor for cardiovascular morbidity and mortality. 3‐hydroxy‐
3‐methylglutaryl coenzyme‐A reductase inhibitors ('statins') are first‐line therapies for …

Background Despite a wide range of medications being available for the prevention of
cardiovascular events such as stroke, myocardial infarction and mortality in both a primary …

Background This represents the first update of this review, which was published in 2012.
Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin …

The current limited evidence suggests that short-acting statins should be given in the
evening whereas long-acting statins could be given at any time of the day with allowing …

Objective: To determine the best time to administer statins for optimal lowering of low-density
lipoprotein cholesterol (LDL-C) by reviewing the clinical evidence evaluating the …