During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

To date the pathophysiology of COVID-19 remains unclear: this represents a factor
determining the current lack of effective treatments. In this paper, we hypothesized a …

Aim Ischemic damage to the brain is linked to an increased rate of morbidity and mortality
worldwide. In certain parts of the world, it remains a leading cause of mortality and the …

Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation
proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation …

There is a current need to develop methods for the sensitive detection of peptide biomarkers
in complex mixtures of molecules, such as biofluids, to enable early disease detection …

Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that
regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely …

Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive
peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling …

Bradykinin, a member of the kallikrein-kinin system (KKS), is associated with an
inflammatory response pathway with diverse vascular permeability functions, including …

Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …