The current unidimensional paradigm of kidney disease detection is incompatible with the
complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has …

It is well established that a large number of patients with acute decompensated heart failure
present with various degrees of heart and kidney dysfunction usually primary disease of …

Endogenous DNA damage can perturb transcription, triggering a multifaceted cellular
response that repairs the damage, degrades RNA polymerase II and shuts down global …

Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

A major drawback of single-cell ATAC-seq (scATAC-seq) is its sparsity, ie, open chromatin
regions with no reads due to loss of DNA material during the scATAC-seq protocol. Here, we …

Currently, no blood biomarker that specifically indicates injury to the proximal tubule of the
kidney has been identified. Kidney injury molecule-1 (KIM-1) is highly upregulated in …

A consensus conference on cardio-renal syndromes (CRS) was held in Venice Italy, in
September 2008 under the auspices of the Acute Dialysis Quality Initiative (ADQI). The …

The term cardiorenal syndrome (CRS) increasingly has been used without a consistent or
well-accepted definition. To include the vast array of interrelated derangements, and to …

Kidney toxicity accounts both for the failure of many drug candidates as well as considerable
patient morbidity. Whereas histopathology remains the gold standard for nephrotoxicity in …

Over the last decade, significant progress has been made in the identification and validation
of novel biomarkers as well as refinements in the use of serum creatinine as a marker of …