Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …

Sulfur (VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced
by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction …

Herein we report the facile syntheses of tetrazoles enabled by FSO2N3 under mild
conditions. FSO2N3 has been shown as the most powerful diazotizing reagent, which …

Molecularly targeted radionuclide therapies (TRTs) struggle with balancing efficacy and
safety, as current strategies to increase tumor absorption often alter drug pharmacokinetics …

The nucleophilic reactivity of RNA 2′-OH groups in water has proven broadly useful in
probing, labeling, and conjugating RNA. To date, reactions selective to ribose 2′-OH have …

Many cereblon (CRBN) ligands have been used to develop proteolysis targeting chimeras
(PROTACs), but all are reversible binders of the E3 ubiquitin ligase. We recently described …