[HTML][HTML] Immune biology of acute myeloid leukemia: implications for immunotherapy
S Khaldoyanidi, D Nagorsen, A Stein… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
Immune surveillance of incipient tumor cells is important for defense against cancer
development. However, active immune evasion is a cancer hallmark. 1 In acute myeloid …
development. However, active immune evasion is a cancer hallmark. 1 In acute myeloid …
Before and after: comparison of legacy and harmonized TCGA genomic data commons' data
We present a systematic analysis of the effects of synchronizing a large-scale, deeply
characterized, multi-omic dataset to the current human reference genome, using updated …
characterized, multi-omic dataset to the current human reference genome, using updated …
Optimized pipeline of MuTect and GATK tools to improve the detection of somatic single nucleotide polymorphisms in whole-exome sequencing data
Background Detecting somatic mutations in whole exome sequencing data of cancer
samples has become a popular approach for profiling cancer development, progression and …
samples has become a popular approach for profiling cancer development, progression and …
[HTML][HTML] Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition
YH Kuo, J Qi, GJ Cook - Experimental hematology, 2016 - Elsevier
Leukemia stem cells (LSCs) are self-renewable, leukemia-initiating populations that are
often resistant to traditional chemotherapy and tyrosine kinase inhibitors currently used for …
often resistant to traditional chemotherapy and tyrosine kinase inhibitors currently used for …
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery
G Simonetti, A Padella, IF do Valle, MC Fontana… - Cancer, 2019 - Wiley Online Library
Background Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases
and correlates with an adverse prognosis. Methods To understand the molecular bases of …
and correlates with an adverse prognosis. Methods To understand the molecular bases of …
[HTML][HTML] Clinical utility of a next-generation sequencing panel for acute myeloid leukemia diagnostics
CM Alonso, M Llop, C Sargas, L Pedrola… - The Journal of Molecular …, 2019 - Elsevier
Next-generation sequencing (NGS) has redefined the genetic landscape of acute myeloid
leukemia (AML), providing new molecular markers for diagnostic and prognostic …
leukemia (AML), providing new molecular markers for diagnostic and prognostic …
Neoantigen Identification, Manufacture, and Use
R Yelensky, A Derti, B Bulik-Sullivan… - US Patent App. 15 …, 2017 - Google Patents
Disclosed herein is a system and methods for determining the alleles, neoantigens, and
vaccine composition as determined on the basis of an individual's tumor mutations. Also …
vaccine composition as determined on the basis of an individual's tumor mutations. Also …
Neoantigen identification, manufacture, and use
R Yelensky, A Derti, B Bulik-Sullivan… - US Patent 10,055,540, 2018 - Google Patents
Disclosed herein is a system and methods for determining the alleles, neoantigens, and
vaccine composition as determined on the basis of an individual's tumor mutations. Also …
vaccine composition as determined on the basis of an individual's tumor mutations. Also …
Xome-Blender: a novel cancer genome simulator
The adoption of next generation sequencing based methods in cancer research allowed for
the investigation of the complex genetic structure of tumor samples. In the last few years …
the investigation of the complex genetic structure of tumor samples. In the last few years …
Acute myeloid leukemia: how do we measure success?
JP Sasine, GJ Schiller - Current hematologic malignancy reports, 2016 - Springer
The development and approval of novel, effective therapies for acute myeloid leukemia
(AML) has lagged behind other malignancies. Judging success of therapy with meaningful …
(AML) has lagged behind other malignancies. Judging success of therapy with meaningful …