Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
Children with Down syndrome (DS) show a spectrum of clinical anomalies, including
cognitive impairment, cardiac malformations, and craniofacial dysmorphy. Moreover …
cognitive impairment, cardiac malformations, and craniofacial dysmorphy. Moreover …
Molecular mechanisms of ETS transcription factor-mediated tumorigenesis
A Kar, A Gutierrez-Hartmann - Critical reviews in biochemistry and …, 2013 - Taylor & Francis
The E26 transformation-specific (ETS) family of transcription factors is critical for
development, differentiation, proliferation and also has a role in apoptosis and tissue …
development, differentiation, proliferation and also has a role in apoptosis and tissue …
Ets2 mediated tumor suppressive function and met oncogene inhibition in human non–small cell lung cancer
M Kabbout, MM Garcia, J Fujimoto, DD Liu… - Clinical cancer …, 2013 - AACR
Purpose: The ETS2 transcription factor is an evolutionarily conserved gene that is
deregulated in cancer. We analyzed the transcriptome of lung adenocarcinomas and normal …
deregulated in cancer. We analyzed the transcriptome of lung adenocarcinomas and normal …
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
JH Klusmann, FJ Godinho, K Heitmann… - Genes & …, 2010 - genesdev.cshlp.org
Oncogene-mediated transformation of hematopoietic cells has been studied extensively, but
little is known about the molecular basis for restriction of oncogenes to certain target cells …
little is known about the molecular basis for restriction of oncogenes to certain target cells …
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
MJ Stankiewicz, JD Crispino - Blood, The Journal of the …, 2009 - ashpublications.org
ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that
have been implicated in human cancer. People with Down syndrome (DS), who are trisomic …
have been implicated in human cancer. People with Down syndrome (DS), who are trisomic …
[HTML][HTML] Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis
Patients with Down syndrome (DS), or trisomy 21 (T21), are at increased risk of transient
abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS). Both TAM …
abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS). Both TAM …
ERG Is a Megakaryocytic Oncogene
Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on
Hsa21. ERG is known to have a crucial role in establishing definitive hematopoiesis and is …
Hsa21. ERG is known to have a crucial role in establishing definitive hematopoiesis and is …
Constitutional aneuploidy and cancer predisposition
I Ganmore, G Smooha, S Izraeli - Human molecular genetics, 2009 - academic.oup.com
Constitutional aneuploidies are rare syndromes associated with multiple developmental
abnormalities and the alterations in the risk for specific cancers. Acquired somatic …
abnormalities and the alterations in the risk for specific cancers. Acquired somatic …
Molecular mechanisms of the genetic predisposition to acute megakaryoblastic leukemia in infants with Down syndrome
Individuals with Down syndrome are genetically predisposed to developing acute
megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML …
megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML …
Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia
J Takeda, K Yoshida, MM Nakagawa, Y Nannya… - Blood Cancer …, 2022 - AACR
Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized
by prominent erythroid proliferation whose molecular basis is poorly understood. To …
by prominent erythroid proliferation whose molecular basis is poorly understood. To …