Cerebellar ataxias with autosomal dominant transmission are rare, but identification of the
associated genes has provided insight into the mechanisms that could underlie other forms …

The autosomal dominant cerebellar ataxias (ADCAs) represent a heterogeneous group of
neurodegenerative diseases with progressive ataxia and cerebellar degeneration. The …

Slowly progressive ataxia accompanied by cerebellar degeneration is often genetic in
origin. The past 15 years have witnessed a revolution in our understanding of the causes of …

OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D).
However, the underlying mechanism is not fully understood. Here, we aimed to …

Intensive scientific research devoted in the recent years to understand the molecular
mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new …

Autosomal dominant spinocerebellar ataxias (SCAs) can present with a large variety of
noncerebellar symptoms, including movement disorders. In fact, movement disorders are …

The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar
atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally …

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive
neurodegenerative diseases characterised by loss of balance and motor coordination due to …

Prevalence of hereditary ataxias varies largely among populations. Several factors are
involved in this variation. In the ataxias caused by repeat expansions, these may include the …

The term SCA refers to a phenotypically and genetically heterogeneous group of autosomal
dominant spinocerebellar ataxias. Phenotypically they present as gait ataxia frequently in …