Synthetic biology is principally concerned with the rational design and engineering of
biologically based parts, devices, or systems. However, biological systems are generally …

Host defense to RNA viruses depends on rapid intracellular recognition of viral RNA by two
cytoplasmic RNA helicases: RIG-I and MDA5. RNA transfection experiments indicate that …

Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of events
resulting in B cell activation. How the BCR becomes signaling-competent upon antigen …

The FcμR receptor for the crystallizable fragment (Fc) of immunoglobulin M (IgM) can
function as a cell-surface receptor for secreted IgM on a variety of cell types. We found here …

The characterization of protein-protein interactions (PPIs) is fundamental to the
understanding of biochemical processes. Many methods have been established to identify …

During development, looping of an enhancer to a promoter is frequently observed in
conjunction with temporal and tissue-specific transcriptional activation. The chromatin …

Heterochromatin is mostly composed of long stretches of repeated DNA sequences prone to
ectopic recombination during double-strand break (DSB) repair. In Drosophila,“safe” …

In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly
phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing …

Many developmental regulators have complex and context-specific roles in different tissues
and stages, making the dissection of their function extremely challenging. As regulatory …

Drosophila cell culture is used as a model system with multiple applications including the
identification of new therapeutic targets in screens, the study of conserved signal …