Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are
implicated in diverse psychiatric and neurodegenerative diseases and are an emerging …

Generic spinal motor neuron identity is established by cooperative binding of programming
transcription factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers. How …

Traditionally, in vitro generation of donor cells for brain repair has been dominated by the
application of extrinsic growth factors and morphogens. Recent advances in cell …

In Parkinson's disease (PD), substantia nigra (SN) dopaminergic (DA) neurons degenerate,
while related ventral tegmental area (VTA) DA neurons remain relatively unaffected. Here …

Brain organoids are three-dimensional cultures that contain multiple types of cells and
cytoarchitectures, and resemble fetal human brain structurally and functionally. These …

Objectives. Human breast milk contains a heterogeneous population of cells that have the
potential to provide a noninvasive source of cells for cell therapy in many neurodegenerative …

Congenital central hypoventilation syndrome (CCHS) is a genetic disorder of
neurodevelopment, with an autosomal dominant transmission, caused by heterozygous …