Adding a transcription-coupled repair pathway
M Saponaro - Nature Cell Biology, 2024 - nature.com
When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it
recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the …
recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the …
[HTML][HTML] Predictomes: A classifier-curated database of AlphaFold-modeled protein-protein interactions
Protein-protein interactions (PPIs) are ubiquitous in biology, yet a comprehensive structural
characterization of the PPIs underlying biochemical processes is lacking. Although …
characterization of the PPIs underlying biochemical processes is lacking. Although …
Changing structures, changing paradigms: NELF helps regulate paused or elongating RNA polymerase II
WF Richter, DJ Taatjes - Molecular Cell, 2024 - Elsevier
Using cryo-EM and biochemical methods, Su and Vos 1 discover an alternative NELF
structural state that enables transcription and switches NELF-RNA polymerase II (RNAPII) …
structural state that enables transcription and switches NELF-RNA polymerase II (RNAPII) …
Clearance of DNA damage-arrested RNAPII is selectively impaired in Cockayne syndrome cells
PJ van der Meer, G Yakoub, Y Nakazawa, T Ogi… - bioRxiv, 2024 - biorxiv.org
Arrest of elongating RNA polymerase II (RNAPII) at DNA lesions initiates transcription-
coupled repair (TCR), involving the concerted action of specific TCR factors, followed by …
coupled repair (TCR), involving the concerted action of specific TCR factors, followed by …