Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

KP De Sousa, I Rossi, M Abdullahi… - Wiley …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer
nanoparticles secreted by most cells. EVs are regarded as important mediators of …

Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

U Erdbrügger, CJ Blijdorp, IV Bijnsdorp… - Journal of …, 2021 - Wiley Online Library
Urine is commonly used for clinical diagnosis and biomedical research. The discovery of
extracellular vesicles (EV) in urine opened a new fast‐growing scientific field. In the last …

Label‐Free Identification of Exosomes using Raman Spectroscopy and Machine Learning

U Parlatan, MO Ozen, I Kecoglu, B Koyuncu, H Torun… - Small, 2023 - Wiley Online Library
Exosomes, nano‐sized extracellular vesicles (EVs) secreted from cells, carry various cargo
molecules reflecting their cells of origin. As EV content, structure, and size are highly …

Scalable trapping of single nanosized extracellular vesicles using plasmonics

C Hong, JC Ndukaife - Nature Communications, 2023 - nature.com
Heterogeneous nanoscale extracellular vesicles (EVs) are of significant interest for disease
detection, monitoring, and therapeutics. However, trapping these nano-sized EVs using …

Advances in analytical technologies for extracellular vesicles

H Yan, Y Li, S Cheng, Y Zeng - Analytical Chemistry, 2021 - ACS Publications
Sensitive early detection, along with effective treatments and solid postoperative monitoring
remain the grand challenges in fighting against human diseases, especially cancer.(1) In …

Surface-enhanced Raman scattering (SERS) spectroscopy for sensing and characterization of exosomes in cancer diagnosis

L Guerrini, E Garcia-Rico, A O'Loghlen, V Giannini… - Cancers, 2021 - mdpi.com
Simple Summary The distinct molecular and biological properties of exosomes, together
with their abundance and stability, make them an ideal target in liquid biopsies for early …

Technological aspects of manufacturing and analytical control of biological nanoparticles

S Brezgin, A Parodi, A Kostyusheva… - Biotechnology …, 2023 - Elsevier
Extracellular vesicles (EVs) are cell-derived biological nanoparticles that gained great
interest for drug delivery. EVs have numerous advantages compared to synthetic …

[HTML][HTML] Advances in the analysis of single extracellular vesicles: A critical review

SH Hilton, IM White - Sensors and actuators reports, 2021 - Elsevier
There is an ever-growing need for new cancer diagnostic approaches that provide earlier
diagnosis as well as richer diagnostic, prognostic, and resistance information. Extracellular …

Overview of extracellular vesicle characterization techniques and introduction to combined reflectance and fluorescence confocal microscopy to distinguish …

C Bağcı, M Sever-Bahcekapili, N Belder… - …, 2022 - spiedigitallibrary.org
Extracellular vesicles (EVs) are nanoparticles (30 to 1000 nm in diameter) surrounded by a
lipid-bilayer which carry bioactive molecules between local and distal cells and participate in …