Considerations for the design of antibody-based therapeutics

DR Goulet, WM Atkins - Journal of pharmaceutical sciences, 2020 - Elsevier
Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …

The impact of glycosylation on the biological function and structure of human immunoglobulins

JN Arnold, MR Wormald, RB Sim, PM Rudd… - Annu. Rev …, 2007 - annualreviews.org
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …

Oral microbial ecology and the role of salivary immunoglobulin A

H Marcotte, MC Lavoie - Microbiology and molecular biology …, 1998 - Am Soc Microbiol
In the oral cavity, indigenous bacteria are often associated with two major oral diseases,
caries and periodontal diseases. These diseases seem to appear following an inbalance in …

The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions

TS Mattu, RJ Pleass, AC Willis, M Kilian… - Journal of Biological …, 1998 - ASBMB
The human serum immunoglobulins IgG and IgA1 are produced in bone marrow and both
interact with specific cellular receptors that mediate biological events. In contrast to IgA1, the …

Bacterial extracellular zinc-containing metalloproteases

CC Häse, RA Finkelstein - Microbiological reviews, 1993 - Am Soc Microbiol
Extracellular zinc-containing metalloproteases are widely distributed in the bacterial world.
The most extensively studied are those which are associated with pathogenic bacteria or …

Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence

M Kilian, J Reinholdt, H LOMHOLT, K Poulsen… - Apmis, 1996 - Wiley Online Library
IgA1 protease activity, which allows bacteria to cleave human IgA1 in the hinge region,
represents a striking example of convergent evolution of a specific property in bacteria …

Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae

SJ King, KR Hippe, JN Weiser - Molecular microbiology, 2006 - Wiley Online Library
Streptococcus pneumoniae produces three surface‐associated exoglycosidases; a
neuraminidase, NanA, a β‐galactosidase, BgaA, and a β‐N‐acetylglucosaminidase, StrH …

Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist

BH Jost, SJ Billington - Antonie Van Leeuwenhoek, 2005 - Springer
Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically
important livestock, causing diseases as diverse as mastitis, liver abscessation and …

Ecology of viridans streptococci in the oral cavity and pharynx

EVG Frandsen, V Pedrazzoli… - Oral microbiology and …, 1991 - Wiley Online Library
Recently published taxonomic studies of viridans streptococci have resulted in several
changes in the nomenclature and definition of oral streptococcal species. With this …

Improving protein quantity and quality—The next level of plant molecular farming

H Liu, MP Timko - International Journal of Molecular Sciences, 2022 - mdpi.com
Plants offer several unique advantages in the production of recombinant pharmaceuticals for
humans and animals. Although numerous recombinant proteins have been expressed in …