Considerations for the design of antibody-based therapeutics
Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …
The impact of glycosylation on the biological function and structure of human immunoglobulins
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
Oral microbial ecology and the role of salivary immunoglobulin A
H Marcotte, MC Lavoie - Microbiology and molecular biology …, 1998 - Am Soc Microbiol
In the oral cavity, indigenous bacteria are often associated with two major oral diseases,
caries and periodontal diseases. These diseases seem to appear following an inbalance in …
caries and periodontal diseases. These diseases seem to appear following an inbalance in …
The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions
The human serum immunoglobulins IgG and IgA1 are produced in bone marrow and both
interact with specific cellular receptors that mediate biological events. In contrast to IgA1, the …
interact with specific cellular receptors that mediate biological events. In contrast to IgA1, the …
Bacterial extracellular zinc-containing metalloproteases
CC Häse, RA Finkelstein - Microbiological reviews, 1993 - Am Soc Microbiol
Extracellular zinc-containing metalloproteases are widely distributed in the bacterial world.
The most extensively studied are those which are associated with pathogenic bacteria or …
The most extensively studied are those which are associated with pathogenic bacteria or …
Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence
M Kilian, J Reinholdt, H LOMHOLT, K Poulsen… - Apmis, 1996 - Wiley Online Library
IgA1 protease activity, which allows bacteria to cleave human IgA1 in the hinge region,
represents a striking example of convergent evolution of a specific property in bacteria …
represents a striking example of convergent evolution of a specific property in bacteria …
Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae
SJ King, KR Hippe, JN Weiser - Molecular microbiology, 2006 - Wiley Online Library
Streptococcus pneumoniae produces three surface‐associated exoglycosidases; a
neuraminidase, NanA, a β‐galactosidase, BgaA, and a β‐N‐acetylglucosaminidase, StrH …
neuraminidase, NanA, a β‐galactosidase, BgaA, and a β‐N‐acetylglucosaminidase, StrH …
Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist
BH Jost, SJ Billington - Antonie Van Leeuwenhoek, 2005 - Springer
Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically
important livestock, causing diseases as diverse as mastitis, liver abscessation and …
important livestock, causing diseases as diverse as mastitis, liver abscessation and …
Ecology of viridans streptococci in the oral cavity and pharynx
EVG Frandsen, V Pedrazzoli… - Oral microbiology and …, 1991 - Wiley Online Library
Recently published taxonomic studies of viridans streptococci have resulted in several
changes in the nomenclature and definition of oral streptococcal species. With this …
changes in the nomenclature and definition of oral streptococcal species. With this …
Improving protein quantity and quality—The next level of plant molecular farming
Plants offer several unique advantages in the production of recombinant pharmaceuticals for
humans and animals. Although numerous recombinant proteins have been expressed in …
humans and animals. Although numerous recombinant proteins have been expressed in …