Antibodies to combat viral infections: development strategies and progress
G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
COVID-19 vaccine development and a potential nanomaterial path forward
MD Shin, S Shukla, YH Chung, V Beiss… - Nature …, 2020 - nature.com
The COVID-19 pandemic has infected millions of people with no clear signs of abatement
owing to the high prevalence, long incubation period and lack of established treatments or …
owing to the high prevalence, long incubation period and lack of established treatments or …
[HTML][HTML] Tecovirimat and the treatment of monkeypox—past, present, and future considerations
A Sherwat, JT Brooks, D Birnkrant… - New England Journal of …, 2022 - Mass Medical Soc
Tecovirimat and the Treatment of Monkeypox — Past, Present, and Future Considerations | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …
England Journal of Medicine Skip to main content The New England Journal of Medicine …
Ebola virus disease
ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
A randomized, controlled trial of Ebola virus disease therapeutics
S Mulangu, LE Dodd, RT Davey Jr… - New England journal …, 2019 - Mass Medical Soc
Background Although several experimental therapeutics for Ebola virus disease (EVD) have
been developed, the safety and efficacy of the most promising therapies need to be …
been developed, the safety and efficacy of the most promising therapies need to be …
Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir
EP Tchesnokov, JY Feng, DP Porter, M Götte - Viruses, 2019 - mdpi.com
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus
that since its emergence in 2012 has caused outbreaks in human populations with case …
that since its emergence in 2012 has caused outbreaks in human populations with case …
Beyond binding: antibody effector functions in infectious diseases
LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …
microorganisms or infected cells. Although preventing pathogen entry is one potential …
Plant molecular farming: A viable platform for recombinant biopharmaceutical production
B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …
steadily, which is attracting global attention for the development of new recombinant protein …
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and …
D Siegel, HC Hui, E Doerffler, MO Clarke, K Chun… - 2017 - ACS Publications
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …