Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from
early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and …

Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are both types
of lupus, yet the characteristics, and differences between them are not fully understood. Here …

Cyclophosphamide (CYC) has been a gold standard of treatment for severe progressive
Systemic Sclerosis (SSc), especially in patients with concomitant interstitial lung disease …

Autoimmune rheumatic diseases (ARD) present a significant global health challenge
characterized by a rising prevalence. These highly heterogeneous diseases involve …

Objectives Determine relationships between skin gene expression and systemic sclerosis
(SSc) clinical disease features, and changes in skin gene expression over time. Methods A …

Background: Systemic sclerosis (SSc) is a rare connective tissue disease that can affect
different organs and has extremely heterogenous presentations. This complexity makes it …

The use of artificial intelligence (AI) in dermatology is an emerging area of interest with
several applications highlighted in the special topic, including the differentiation of benign …

Autoantibodies (Aabs) are frequent in systemic sclerosis (SSc). Although recognized as
potent biomarkers, their pathogenic role is debated. This study explored the effect of purified …

Stem cell transplantation has been investigated as treatment for severe and progressive
systemic sclerosis (SSc) for the past 25 years. To date, more than 1000 SSc patients have …