Glycopeptide and lipoglycopeptide antibiotics

D Kahne, C Leimkuhler, W Lu, C Walsh - Chemical reviews, 2005 - ACS Publications
Vancomycin and teicoplanin are the two glycopeptide antibiotics that are used clinically, and
the emergence of resistance to them poses a serious threat to human health. Some …

Natural‐product sugar biosynthesis and enzymatic glycodiversification

CJ Thibodeaux, CE Melançon III… - Angewandte Chemie …, 2008 - Wiley Online Library
Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Natural products version 2.0: connecting genes to molecules

CT Walsh, MA Fischbach - Journal of the American Chemical …, 2010 - ACS Publications
Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules

RW Gantt, P Peltier-Pain, JS Thorson - Natural product reports, 2011 - pubs.rsc.org
Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Glycopeptide antibiotic biosynthesis

G Yim, MN Thaker, K Koteva, G Wright - The Journal of antibiotics, 2014 - nature.com
Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …

Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance

N Waglechner, AG McArthur, GD Wright - Nature microbiology, 2019 - nature.com
Glycopeptide antibiotics are produced by Actinobacteria through biosynthetic gene clusters
that include genes supporting their regulation, synthesis, export and resistance. The …

[图书][B] Carbohydrate-based drug discovery, 2 volume set

CH Wong - 2003 - books.google.com
Die Suche nach Medikamenten mit neuen oder verbesserten Eigenschaften hat das
Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt …

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways

ES Sattely, MA Fischbach, CT Walsh - Natural product reports, 2008 - pubs.rsc.org
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways -
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …

Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction

IC Schoenhofen, DJ McNally, JR Brisson… - …, 2006 - academic.oup.com
Flagellin glycosylation is a necessary modification allowing flagellar assembly, bacterial
motility, colonization, and hence virulence for the gastrointestinal pathogen Helicobacter …

Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones:  Novel Glycopeptides,

HC Losey, MW Peczuh, Z Chen, US Eggert… - Biochemistry, 2001 - ACS Publications
The glycopeptides vancomycin and teicoplanin are clinically important antibiotics. The
carbohydrate portions of these molecules affect biological activity, and there is great interest …