Glycopeptide and lipoglycopeptide antibiotics
D Kahne, C Leimkuhler, W Lu, C Walsh - Chemical reviews, 2005 - ACS Publications
Vancomycin and teicoplanin are the two glycopeptide antibiotics that are used clinically, and
the emergence of resistance to them poses a serious threat to human health. Some …
the emergence of resistance to them poses a serious threat to human health. Some …
Natural‐product sugar biosynthesis and enzymatic glycodiversification
CJ Thibodeaux, CE Melançon III… - Angewandte Chemie …, 2008 - Wiley Online Library
Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …
derive their activities from sugar substituents. Changing the structures of these sugars can …
Natural products version 2.0: connecting genes to molecules
CT Walsh, MA Fischbach - Journal of the American Chemical …, 2010 - ACS Publications
Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …
continue to be important as drugs, biological probes, and targets of study for synthetic and …
Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules
RW Gantt, P Peltier-Pain, JS Thorson - Natural product reports, 2011 - pubs.rsc.org
Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …
Glycopeptide antibiotic biosynthesis
Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …
Phylogenetic reconciliation reveals the natural history of glycopeptide antibiotic biosynthesis and resistance
Glycopeptide antibiotics are produced by Actinobacteria through biosynthetic gene clusters
that include genes supporting their regulation, synthesis, export and resistance. The …
that include genes supporting their regulation, synthesis, export and resistance. The …
[图书][B] Carbohydrate-based drug discovery, 2 volume set
CH Wong - 2003 - books.google.com
Die Suche nach Medikamenten mit neuen oder verbesserten Eigenschaften hat das
Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt …
Interesse am pharmazeutischen Potenzial von Kohlenhydraten enorm verstärkt. Dies gilt …
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways
ES Sattely, MA Fischbach, CT Walsh - Natural product reports, 2008 - pubs.rsc.org
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways -
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …
Natural Product Reports (RSC Publishing) DOI:10.1039/B801747F Royal Society of Chemistry …
Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction
IC Schoenhofen, DJ McNally, JR Brisson… - …, 2006 - academic.oup.com
Flagellin glycosylation is a necessary modification allowing flagellar assembly, bacterial
motility, colonization, and hence virulence for the gastrointestinal pathogen Helicobacter …
motility, colonization, and hence virulence for the gastrointestinal pathogen Helicobacter …
Tandem Action of Glycosyltransferases in the Maturation of Vancomycin and Teicoplanin Aglycones: Novel Glycopeptides,
HC Losey, MW Peczuh, Z Chen, US Eggert… - Biochemistry, 2001 - ACS Publications
The glycopeptides vancomycin and teicoplanin are clinically important antibiotics. The
carbohydrate portions of these molecules affect biological activity, and there is great interest …
carbohydrate portions of these molecules affect biological activity, and there is great interest …