Neurophysiology of HCN channels: from cellular functions to multiple regulations
C He, F Chen, B Li, Z Hu - Progress in neurobiology, 2014 - Elsevier
Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …
involved in multiple physiological processes.•HCN channels are excellent targets of various …
Exploring HCN channels as novel drug targets
O Postea, M Biel - Nature reviews Drug discovery, 2011 - nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on …
h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex
Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels …
differences in rodent versus human neuronal physiology. We tested whether h-channels …
Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - Elsevier
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
Cortical HCN channels: function, trafficking and plasticity
MM Shah - The Journal of physiology, 2014 - Wiley Online Library
The hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels belong to the
superfamily of voltage‐gated potassium ion channels. They are, however, activated by …
superfamily of voltage‐gated potassium ion channels. They are, however, activated by …
Cardiac and neuronal HCN channelopathies
I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease
CS Chan, KE Glajch, TS Gertler, JN Guzman… - Nature …, 2011 - nature.com
Parkinson's disease is a common neurodegenerative disorder characterized by a profound
motor disability that is traceable to the emergence of synchronous, rhythmic spiking in …
motor disability that is traceable to the emergence of synchronous, rhythmic spiking in …
Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes …
Output properties of neurons are greatly shaped by voltage-gated ion channels, whose
biophysical properties and localization within axodendritic compartments serve to …
biophysical properties and localization within axodendritic compartments serve to …
Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive
Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation
therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction …
therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction …