Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Aberrant expression of histone deacetylase 6 (HDAC6) is greatly involved in neoplasm
metastasis, which is a leading cause of colon cancer related death. Thus, deep …

Our study investigates the biochemical and functional impact of selective histone
deacetylase 6 (HDAC6) inhibitors, a promising class of novel therapeutics, in several cancer …

Cell motility is a crucial biological process that plays a critical role in the development of
multicellular organisms and is essential for tissue formation and regeneration. However …

Histone deacetylases (HDACs) are enzymes that play a key role in regulating gene
expression by remodeling chromatin structure. An imbalance of histone acetylation caused …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …

Alterations of the epigenetic machinery, affecting multiple biological functions, represent a
major hallmark enabling the development of tumors. Among epigenetic regulatory proteins …

Histone deacetylase (HDAC) inhibitors (HDACis) have demonstrated activity in
hematological and solid malignancies. Vorinostat, romidepsin, belinostat, and panobinostat …

Mice with histone deacetylase 6 (HDAC6) deficiency grow and develop normally but exhibit
impaired immune response. The molecular mechanisms for this phenotype remain largely …