Objective: One of the most important side effects of opioids is their influence on the electrical
activity of the heart. This review focusses on the effects of opioids on QT interval …

Objective The use of opioids to treat chronic pain has come under increased scrutiny, as
such use has been associated with significant risk of death, with limited data regarding the …

Pain has always been an important part of human immunodeficiency virus (HIV) disease
and its experience for patients. In this guideline, we review the types of chronic pain …

Objective Several psychiatric medications have the potential to prolong the QTc interval and
subsequently increase the risk for ventricular arrhythmias such as torsades de pointes (TdP) …

Objective Methadone prolongs cardiac conduction, from mild corrected QT (QTc)
prolongation to torsades de pointes and ventricular fibrillation, in adults. However …

Context: The effect of methadone on corrected QT interval (QTc) in patients with cancer pain
is not well-known. Objectives: To describe and characterize the effect of low-, moderate …

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased
risk of torsades de pointes. The acquired form is most often attributable to administration of …

Abstract Background/Purpose Mortality associated with prescription opioids has significantly
increased over the past few decades and is considered a global pandemic. Prescribed …

Providing safe and effective care for patients with chronic pain undergoing neurosurgery
requires a carefully planned anesthetic strategy. If the anesthesiologist errs on the side of …

A recent Pro-Con article1 and an accompanying editorial2 bring to the fore the use of
methadone in the perioperative period. This is timely and important. Methadone is frequently …