[HTML][HTML] Protective effects of natural products against myocardial ischemia/reperfusion: Mitochondria-targeted therapeutics
X Su, M Zhou, Y Li, J Zhang, N An, F Yang… - Biomedicine & …, 2022 - Elsevier
Patients with ischemic heart disease receiving reperfusion therapy still need to face left
ventricular remodeling and heart failure after myocardial infarction. Reperfusion itself …
ventricular remodeling and heart failure after myocardial infarction. Reperfusion itself …
Sphingolipid metabolism controls mammalian heart regeneration
X Ji, Z Chen, Q Wang, B Li, Y Wei, Y Li, J Lin, W Cheng… - Cell Metabolism, 2024 - cell.com
Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle
arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision …
arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision …
Sustained AT1R stimulation induces upregulation of growth factors in human cardiac fibroblasts via Gαq/TGF-β/ERK signaling that influences myocyte hypertrophy
R Duangrat, W Parichatikanond, NP Morales… - European Journal of …, 2022 - Elsevier
Stimulation of angiotensin II receptor (ATR) with angiotensin II (Ang II) accelerates cardiac
fibroblast activation, resulting in upregulation of cytokines and growth factors. Growth factors …
fibroblast activation, resulting in upregulation of cytokines and growth factors. Growth factors …
Mitochondrial damage in myocardial Ischemia/Reperfusion injury and application of natural plant products
X Su, M Zhou, Y Li, N An, F Yang… - Oxidative Medicine …, 2022 - Wiley Online Library
Ischemic heart disease (IHD) is currently one of the leading causes of death among
cardiovascular diseases worldwide. In addition, blood reflow and reperfusion paradoxically …
cardiovascular diseases worldwide. In addition, blood reflow and reperfusion paradoxically …
Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues
JS Reyat, A di Maio, B Grygielska, J Pike… - Frontiers in …, 2023 - frontiersin.org
Introduction Recent advances in human cardiac 3D approaches have yielded progressively
more complex and physiologically relevant culture systems. However, their application in the …
more complex and physiologically relevant culture systems. However, their application in the …
Gαq protein-biased ligand of angiotensin II type 1 receptor mediates myofibroblast differentiation through TGF-β1/ERK axis in human cardiac fibroblasts
W Parichatikanond, R Duangrat, S Mangmool - European Journal of …, 2023 - Elsevier
Angiotensin II receptors are members of G protein-coupled receptor superfamily that
manifest biased signals toward G protein-and β-arrestin-dependent pathways. However, the …
manifest biased signals toward G protein-and β-arrestin-dependent pathways. However, the …
Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats
G Papini, G Furini, M Matteucci, V Biemmi… - Journal of Translational …, 2023 - Springer
Abstract Background Exosomes (EXOs), tiny extracellular vesicles that facilitate cell–cell
communication, are being explored as a heart failure treatment, although the features of the …
communication, are being explored as a heart failure treatment, although the features of the …
Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT1R/Gαq-Mediated …
R Duangrat, W Parichatikanond… - International Journal of …, 2023 - mdpi.com
Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-
1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the …
1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the …
Sevoflurane improves ventricular conduction by exosomes derived from rat cardiac fibroblasts after hypothermic global ischemia-reperfusion injury
Y Ma, Y Cao, H Gao, R Tong, J Yi, Z Zhang… - Drug design …, 2023 - Taylor & Francis
Purpose This study investigated the effect of exosomes derived from sevoflurane-treated
cardiac fibroblasts (Sev-CFs-Exo) on reperfusion arrhythmias (RA), ventricular conduction …
cardiac fibroblasts (Sev-CFs-Exo) on reperfusion arrhythmias (RA), ventricular conduction …
[HTML][HTML] BACH1 impairs hepatocyte regeneration after hepatectomy with repeated ischemia/reperfusion by reprogramming energy metabolism and exacerbating …
Y Hu, J Li, L Hu, F Liu, R Chen, L Xu, Z Tang… - Biochemical …, 2024 - Elsevier
Abstract BTB and CNC homology 1 (BACH1) regulates biological processes, including
energy metabolism and oxidative stress. Insufficient liver regeneration after hepatectomy …
energy metabolism and oxidative stress. Insufficient liver regeneration after hepatectomy …