XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment
Single-cell RNA sequencing (scRNA-seq) of tissues has revealed remarkable heterogeneity
of cell types and states but does not provide information on the spatial organization of cells …
of cell types and states but does not provide information on the spatial organization of cells …
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19
HY Zheng, M Xu, CX Yang, RR Tian, M Zhang… - Signal transduction and …, 2020 - nature.com
Understanding the processes of immune regulation in patients infected with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment …
Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling
Thymic involution is a key factor in human immune aging, leading to reduced thymic output
and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the …
and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the …
Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
M Heimli, ST Flåm, HS Hjorthaug, D Trinh… - Frontiers in …, 2023 - frontiersin.org
To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are
negatively selected, however, divergence into tolerogenic, agonist selected lineages …
negatively selected, however, divergence into tolerogenic, agonist selected lineages …
Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing
R Trifiletti, HM Lachman, O Manusama, D Zheng… - Scientific reports, 2022 - nature.com
Abrupt onset of severe neuropsychiatric symptoms including obsessive–compulsive
disorder, tics, anxiety, mood swings, irritability, and restricted eating is described in children …
disorder, tics, anxiety, mood swings, irritability, and restricted eating is described in children …
Differences in H3K4me3 and chromatin accessibility contribute to altered T‐cell receptor signaling in neonatal naive CD4 T cells
JR Bermick, P Issuree, A denDekker… - Immunology and cell …, 2022 - Wiley Online Library
Neonatal CD4+ T cells have reduced or delayed T‐cell receptor (TCR) signaling responses
compared with adult cells, but the mechanisms underlying this are poorly understood. This …
compared with adult cells, but the mechanisms underlying this are poorly understood. This …
Transcriptome signature of Vγ9Vδ2 T cells treated with phosphoantigens and notch inhibitor reveals interplay between TCR and notch signaling pathways
A Madhok, SA Bhat, CS Philip, SK Sureshbabu… - Frontiers in …, 2021 - frontiersin.org
Gamma delta (γδ) T cells, especially the Vγ9Vδ2 subtype, have been implicated in cancer
therapy and thus have earned the spotlight in the past decade. Although one of the most …
therapy and thus have earned the spotlight in the past decade. Although one of the most …
Comparative transcriptome analysis of T lymphocyte subpopulations and identification of critical regulators defining porcine thymocyte identity
P Han, W Zhang, D Wang, Y Wu, X Li, S Zhao… - Frontiers in …, 2024 - frontiersin.org
Introduction The development and migration of T cells in the thymus and peripheral tissues
are crucial for maintaining adaptive immunity in mammals. However, the regulatory …
are crucial for maintaining adaptive immunity in mammals. However, the regulatory …
The gene expression profile and cell of origin of canine peripheral T-cell lymphoma
E Owens, L Harris, A Harris, J Yoshimoto, R Burnett… - BMC cancer, 2024 - Springer
Background Peripheral T-cell lymphoma (PTCL) refers to a heterogenous group of T-cell
neoplasms with poor treatment responses and survival times. Canine PTCL clinically and …
neoplasms with poor treatment responses and survival times. Canine PTCL clinically and …
HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients
Ó Brochado, I Martínez, J Berenguer… - Journal of Biomedical …, 2021 - Springer
Objective To evaluate the impact of hepatitis C virus (HCV) elimination via interferon (IFN)-
based therapy on gene expression profiles related to the immune system in HIV/HCV …
based therapy on gene expression profiles related to the immune system in HIV/HCV …