In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive
molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has …

The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

Despite decades of research, brain tumours remain among the deadliest of all forms of
cancer. The ability of these tumours to resist almost all conventional and novel treatments …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Surgery
followed by chemotherapy and radiotherapy remains the standard treatment strategy for …

The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-
borne factors. Although BBB dysfunction is a hallmark of several neurological disorders …

Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …