Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …

Small-angle scattering of X-rays (SAXS) is an established method to study the overall
structure and structural transitions of biological macromolecules in solution. For folded …

Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …

Plasmonic nanoparticles are increasingly utilized in biomedical applications including
imaging, diagnostics, drug delivery, and plasmonic photothermal therapy (PPT). PPT …

Protein aggregation has now become recognised as an important and generic aspect of
protein energy landscapes. Since the discovery that numerous human diseases are caused …

Allosteric transition, defined as conformational changes induced by ligand binding, is one of
the fundamental properties of proteins. Allostery has been observed and characterized in …

Tauopathies are neurodegenerative diseases characterized by intracellular amyloid
deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with …

Intrinsically disordered proteins play important roles throughout biology, yet our
understanding of the relationship between their sequences, structural properties, and …

Unconstrained atomistic simulations of intrinsically disordered proteins and peptides (IDP)
remain a challenge: widely used,“general purpose” water models tend to favor overly …