Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

Metastasis is the cause of death for patients with many types of cancer, but the process of
tumour cell dissemination is poorly understood. As primary tumours are three-dimensional …

Cancer-induced immune responses affect tumour progression and therapeutic response. In
multiple murine models and clinical datasets, we identified large variations of neutrophils …

It has recently become apparent that the immune system can cure cancer. In some of these
strategies, the antigen targets are preidentified and therapies are custom-made against …

Cancer control by adaptive immunity involves a number of defined death,,,,,,, and clearance,,
mechanisms. However, efficient inhibition of exponential cancer growth by T cells and …

Evidence for the potent influence of stromal organization and function on invasion and
metastasis of breast tumors is ever growing. We have performed a rigorous examination of …

Immunomodulators that remodel the tumor immunosuppressive microenvironment have
been combined with anti–programmed death 1 (α-PD1) or anti–programmed death ligand 1 …

It is widely accepted that metastasis is a late event in cancer progression. Here, however, we
show that tumor cells can disseminate systemically from earliest epithelial alterations in HER …

Animal models are powerful tools to analyze the mechanism of the induction of human
breast cancer. Here we report a detailed analysis of mammary tumor progression in one …

Tumor cells gain a survival/growth advantage by adapting their metabolism to respond to
environmental stress, a process known as metabolic transformation. The best-known aspect …