Coronary microvascular dysfunction (CMD) encompasses several pathogenetic
mechanisms involving coronary microcirculation and plays a major role in determining …

Coronary computed tomography angiography (CTA) has emerged as a noninvasive method
for direct visualization of coronary artery disease, with previous studies demonstrating high …

Radionuclide myocardial perfusion imaging (MPI) is among the most commonly performed
diagnostic tests in cardiology. Although the diagnostic and prognostic applications of …

Background—Coronary flow reserve (CFR), an integrated measure of focal, diffuse, and
small-vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We …

Cardiac imaging has a pivotal role in the prevention, diagnosis and treatment of ischaemic
heart disease. SPECT is most commonly used for clinical myocardial perfusion imaging …

Ischemic heart disease (IHD) is commonly recognized as the consequence of coronary
atherosclerosis and obstructive coronary artery disease (CAD). However, a significant …

Background The clinical significance of coronary-artery stenoses of moderate severity can
be difficult to determine. Myocardial fractional flow reserve (FFR) is a new index of the …

Background—Discordance between fractional flow reserve (FFR) and coronary flow velocity
reserve (CFVR) may reflect important coronary pathophysiology but usually remains …

Aims The present analysis addresses the potential clinical and physiologic significance of
discordance in severity of coronary artery disease between the angiogram and fractional …

Background Fractional flow reserve (FFR), defined as the ratio of maximum flow in the
presence of a stenosis to normal maximum flow, is a lesion-specific index of stenosis …