Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Growing tumors face two major metabolic challenges—how to meet the bioenergetic and
biosynthetic demands of increased cell proliferation, and how to survive environmental …

Membrane fusion is generally controlled by Rabs, soluble N-ethylmaleimide–sensitive factor
attachment protein receptors (SNAREs), and tethering complexes. Syntaxin 17 (STX17) was …

Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking.
In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15 …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …

Autophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular
components. Degradation of mitochondria via autophagy (mitophagy) is involved in a …

BH3 domains were originally discovered in the context of apoptosis regulators and they
mediate binding of proapoptotic Bcl-2 family members to antiapoptotic Bcl-2 family …

Autophagy is an evolutionarily conserved and exquisitely regulated self-eating cellular
process with important biological functions. Phosphatidylinositol 3-kinases (PtdIns3Ks) and …

Since the first discovery of the lysosome and the definition of autophagy by Christian de
Duve more than 60 years ago, research on autophagy, a process targeting cytoplasmic …

Glioblastoma multiforme is the most common and the most aggressive primary brain tumor. It
is characterized by a high degree of hypoxia and also by a remarkable resistance to therapy …