Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Recent advances in the synthesis of biologically active spirooxindoles

MMM Santos - Tetrahedron, 2014 - Elsevier
The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …

Natural compounds as medical strategies in the prevention and treatment of psychiatric disorders seen in neurological diseases

E Küpeli Akkol, I Tatlı Çankaya… - Frontiers in …, 2021 - frontiersin.org
Psychiatric disorders are frequently encountered in many neurological disorders, such as
Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and …

Plant alkaloids as drug leads for Alzheimer's disease

YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …

[HTML][HTML] Role of plant derived alkaloids and their mechanism in neurodegenerative disorders

G Hussain, A Rasul, H Anwar, N Aziz… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Q Zhang, JJ Zhao, J Xu, F Feng, W Qu - Journal of Ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance The genus Uncaria belongs to the family
Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and …

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

Attenuation of Nrf2/Keap1/ARE in Alzheimer's disease by plant secondary metabolites: A mechanistic review

S Fakhri, M Pesce, A Patruno, SZ Moradi, A Iranpanah… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a progressive neuronal/cognitional dysfunction, leading to
disability and death. Despite advances in revealing the pathophysiological mechanisms …

Phellodendri cortex: a phytochemical, pharmacological, and pharmacokinetic review

Y Sun, GB Lenon, AWH Yang - … ‐Based Complementary and …, 2019 - Wiley Online Library
Background. Phellodendri Cortex (PC) or Huang Bai. According to the scientific database of
China Plant Species and Chinese pharmacopeia 2015 edition, PC has two main species …

Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside

R Sharma, K Kuca, E Nepovimova… - Expert review of …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a progressive, neurodegenerative disorder
prevalent worldwide among elderly populations. Owing to limited efficacy, side effects, and …