Pro-inflammatory cytokines: The link between obesity and osteoarthritis
T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …
Interleukin-1 and related cytokines in the regulation of inflammation and immunity
Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
the growing understanding of its context-dependent roles and advances in the clinic. Recent …
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
limiting systemic inflammatory responses in humans that were not predicted from preclinical …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
MI Gabitto, KJ Travaglini, VM Rachleff, ES Kaplan… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression
Glioblastoma (GBM), a highly lethal brain cancer, is notorious for immunosuppression, but
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
the mechanisms remain unclear. Here, we documented a temporospatial patterning of tumor …
[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
Inflammasome signaling and regulation of interleukin-1 family cytokines
AH Chan, K Schroder - Journal of Experimental Medicine, 2019 - rupress.org
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …
The pyrin inflammasome in health and disease
The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential …
H Zalpoor, A Akbari, A Samei… - Cellular & Molecular …, 2022 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …
[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …
microbial pathogens, irritants, or toxic cellular components. The primary physical …