Minimal" Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles

PL Rodriguez, T Harada, DA Christian, DA Pantano… - Science, 2013 - science.org
Foreign particles and cells are cleared from the body by phagocytes that must also
recognize and avoid clearance of" self" cells. The membrane protein CD47 is reportedly a" …

Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin

N Romani, BE Clausen, P Stoitzner - Immunological reviews, 2010 - Wiley Online Library
Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia.
The best studied example is the LC of the epidermis. By electron microscopy, their …

Potent SARS-CoV-2-specific T cell immunity and low anaphylatoxin levels correlate with mild disease progression in COVID-19 patients

E Lafon, G Diem, C Witting, V Zaderer… - Frontiers in …, 2021 - frontiersin.org
T cells play a fundamental role in the early control and clearance of many viral infections of
the respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically …

Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self'CD47, and target physical properties

NG Sosale, KR Spinler, C Alvey, DE Discher - Current opinion in …, 2015 - Elsevier
Highlights•Mononuclear phagocyte system (MPS), especially macrophages, must be
selective.•Phagocytosis is not just driven by antibodies on a target.•Phagocytosis is also …

SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19

S Sahanic, R Hilbe, C Dünser, P Tymoszuk… - Heliyon, 2023 - cell.com
Abstract Background Toll-like receptors (TLRs) play a pivotal role in the immunologic
response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Non-neutralizing antibodies directed against HIV and their functions

LM Mayr, B Su, C Moog - Frontiers in immunology, 2017 - frontiersin.org
B cells produce a plethora of anti-HIV antibodies (Abs) but only few of them exhibit
neutralizing activity. This was long considered a profound limitation for the enforcement of …

Engineering macrophages to eat cancer: from “marker of self” CD47 and phagocytosis to differentiation

C Alvey, DE Discher - Journal of leukocyte biology, 2017 - academic.oup.com
The ability of a macrophage to engulf and break down invading cells and other targets
provides a first line of immune defense in nearly all tissues. This defining ability to “phagos” …

Tetraspanins as organizers of antigen-presenting cell function

ML Saiz, V Rocha-Perugini… - Frontiers in …, 2018 - frontiersin.org
Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells.
APCs internalize and process antigens, producing immunogenic peptides that enable …

Extensive complement-dependent enhancement of HIV-1 by autologous non-neutralising antibodies at early stages of infection

S Willey, MMI Aasa-Chapman, S O'Farrell, P Pellegrino… - Retrovirology, 2011 - Springer
Background Non-neutralising antibodies to the envelope glycoprotein are elicited during
acute HIV-1 infection and are abundant throughout the course of disease progression …

Generation of human monocyte-derived dendritic cells from whole blood

W Posch, C Lass-Flörl… - Journal of visualized …, 2016 - pmc.ncbi.nlm.nih.gov
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood - PMC Back to Top
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