Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease

A Abbate, S Toldo, C Marchetti, J Kron… - Circulation …, 2020 - Am Heart Assoc
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

[HTML][HTML] Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review

FS Zhang, QZ He, CH Qin, PJ Little, JP Weng… - Acta Pharmacologica …, 2022 - nature.com
Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Macrophage‐mediated cholesterol handling in atherosclerosis

DA Chistiakov, YV Bobryshev… - Journal of cellular and …, 2016 - Wiley Online Library
Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes
attracted by pro‐inflammatory stimuli attach to the inflamed vascular endothelium and …

[HTML][HTML] Foam cells in atherosclerosis

XH Yu, YC Fu, DW Zhang, K Yin, CK Tang - Clinica chimica acta, 2013 - Elsevier
Atherosclerosis is a chronic disease characterized by the deposition of excessive
cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence …

The role of cytokines in the development of atherosclerosis

AR Fatkhullina, IO Peshkova, EK Koltsova - Biochemistry (Moscow), 2016 - Springer
Atherosclerosis contributes to the development of many cardiovascular diseases, which
remain the leading cause of death in developed countries. Atherosclerosis is a chronic …

IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline

AKY Fu, KW Hung, MYF Yuen, X Zhou… - Proceedings of the …, 2016 - National Acad Sciences
Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …

Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study

TJ Wang, KC Wollert, MG Larson, E Coglianese… - Circulation, 2012 - Am Heart Assoc
Background—Biomarkers for predicting cardiovascular events in community-based
populations have not consistently added information to standard risk factors. A limitation of …

Recent advances on the role of cytokines in atherosclerosis

H Ait-Oufella, S Taleb, Z Mallat… - … , thrombosis, and vascular …, 2011 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and
adaptive immune responses. Inflammation controls the development and the destabilization …