Inflaming the brain with iron
Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …
Brain iron metabolism and CNS diseases
A Thirupathi, YZ Chang - Brain Iron Metabolism and CNS Diseases, 2019 - Springer
Iron is the most abundant trace element in the human body. It is well known that iron is an
important component of hemoglobin involved in the transport of oxygen. As a component of …
important component of hemoglobin involved in the transport of oxygen. As a component of …
Inflammation alters the expression of DMT 1, FPN 1 and hepcidin, and it causes iron accumulation in central nervous system cells
P Urrutia, P Aguirre, A Esparza, V Tapia… - Journal of …, 2013 - Wiley Online Library
Inflammation and iron accumulation are present in a variety of neurodegenerative diseases
that include Alzheimer's disease and Parkinson's disease. The study of the putative …
that include Alzheimer's disease and Parkinson's disease. The study of the putative …
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
A McIntosh, V Mela, C Harty, AM Minogue… - Brain …, 2019 - Wiley Online Library
Among the changes that typify Alzheimer's disease (AD) are neuroinflammation and
microglial activation, amyloid deposition perhaps resulting from compromised microglial …
microglial activation, amyloid deposition perhaps resulting from compromised microglial …
Brain iron metabolism dysfunction in Parkinson's disease
H Jiang, J Wang, J Rogers, J Xie - Molecular neurobiology, 2017 - Springer
Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …
Brain iron metabolism, redox balance and neurological diseases
G Gao, L You, J Zhang, YZ Chang, P Yu - Antioxidants, 2023 - mdpi.com
The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease
and stroke, is increasing. An increasing number of studies have correlated these diseases …
and stroke, is increasing. An increasing number of studies have correlated these diseases …
The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease
AA Raha, RA Vaishnav, RP Friedland… - Acta neuropathologica …, 2013 - Springer
Background The pathological features of the common neurodegenerative conditions,
Alzheimer's disease (AD), Parkinson's disease and multiple sclerosis are all known to be …
Alzheimer's disease (AD), Parkinson's disease and multiple sclerosis are all known to be …
Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism
Y Zhao, Z Xin, N Li, S Chang, Y Chen, L Geng… - Free Radical Biology …, 2018 - Elsevier
In order to discover new drug delivery approaches and to understand the mechanism of iron
overload in cerebral ischemia/reperfusion (I/R), we aimed to investigate the effects of …
overload in cerebral ischemia/reperfusion (I/R), we aimed to investigate the effects of …
[HTML][HTML] Epigallocatechin gallate has a neurorescue effect in a mouse model of Parkinson disease
Background Parkinson disease (PD) is a neurodegenerative disorder that has been
associated with many factors, including oxidative stress, inflammation, and iron …
associated with many factors, including oxidative stress, inflammation, and iron …
Mitochondrial iron metabolism and its role in neurodegeneration
MP Horowitz, JT Greenamyre - Journal of Alzheimer's disease, 2010 - content.iospress.com
In addition to their well-established role in providing the cell with ATP, mitochondria are the
source of iron-sulfur clusters (ISCs) and heme–prosthetic groups that are utilized by proteins …
source of iron-sulfur clusters (ISCs) and heme–prosthetic groups that are utilized by proteins …