Next-generation sequencing in oncology: genetic diagnosis, risk prediction and cancer classification

R Kamps, RD Brandão, BJ van den Bosch… - International journal of …, 2017 - mdpi.com
Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Computational prediction and validation of tumor-associated neoantigens

V Roudko, B Greenbaum, N Bhardwaj - Frontiers in Immunology, 2020 - frontiersin.org
Tumor progression is typically accompanied by an accumulation of driver and passenger
somatic mutations. A handful of those mutations occur in protein coding genes which …

Origin and evolution of the octoploid strawberry genome

PP Edger, TJ Poorten, R VanBuren, MA Hardigan… - Nature …, 2019 - nature.com
Cultivated strawberry emerged from the hybridization of two wild octoploid species, both
descendants from the merger of four diploid progenitor species into a single nucleus more …

Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit

F Cardoso, RGJ Klein Wolterink, C Godinho-Silva… - Nature, 2021 - nature.com
Signals from sympathetic neurons and immune cells regulate adipocytes and thereby
contribute to fat tissue biology. Interactions between the nervous and immune systems have …

A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome

International Wheat Genome Sequencing Consortium … - Science, 2014 - science.org
An ordered draft sequence of the 17-gigabase hexaploid bread wheat (Triticum aestivum)
genome has been produced by sequencing isolated chromosome arms. We have annotated …

Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts

YS Bogliotti, J Wu, M Vilarino… - Proceedings of the …, 2018 - National Acad Sciences
Embryonic stem cells (ESCs) are derived from the inner cell mass of preimplantation
blastocysts. From agricultural and biomedical perspectives, the derivation of stable ESCs …

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations

ZN Abbas, AZ Al-Saffar, SM Jasim, GM Sulaiman - Scientific Reports, 2023 - nature.com
Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …

Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

JJ Engel, CI van der Made, N Keur… - Frontiers in …, 2023 - frontiersin.org
Background Dexamethasone improves the survival of COVID-19 patients in need of
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …

Construction of a map-based reference genome sequence for barley, Hordeum vulgare L.

S Beier, A Himmelbach, C Colmsee, XQ Zhang… - Scientific Data, 2017 - nature.com
Barley (Hordeum vulgare L.) is a cereal grass mainly used as animal fodder and raw
material for the malting industry. The map-based reference genome sequence of barley …

Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies

B Roskams-Hieter, HJ Kim, P Anur, JT Wagner… - NPJ Precision …, 2022 - nature.com
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …