Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …

Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium
tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort …

The search for new and efficient pharmaceuticals is a constant struggle for medicinal
chemists. New substances are needed in order to treat different pathologies affecting the …

A series of novel Ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues (4a-r)
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …

Virulence-associated protein B and C toxin-antitoxin (TA) systems are widespread in
prokaryotes, but their precise role in physiology is poorly understood. We have functionally …

The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M …

The riboflavin biosynthetic pathway is a promising target for the development of novel
antimycobacterial drugs given the lack of riboflavin transporter in M. tuberculosis. Herein, a …

Tuberculosis (TB) is a global health concern, and this situation has further worsened due to
the emergence of drug-resistant strains and the failure of BCG vaccine to impart protection …

Novel analogues of fluorophenyl tethered thiazoles 7a-k and chalcones 10a-k were
designed through molecular hybridization approach. All the synthesized final compounds …