The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Surviving a single infection often results in lifelong immunity to the infecting pathogen. Such
protection is mediated, in large part, by two main B cell memory 'walls'—namely, long-lived …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-
induced gene expression in diverse cell types. Cellular responses to NF-κB activation are …

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and is
notorious for its heterogeneity, aggressive nature, and the frequent development of …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …