Tracking cancer progression: From circulating tumor cells to metastasis

F Castro-Giner, N Aceto - Genome medicine, 2020 - Springer
The analysis of circulating tumor cells (CTCs) is an outstanding tool to provide insights into
the biology of metastatic cancers, to monitor disease progression and with potential for use …

Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Determination of PD-L1 expression in circulating tumor cells of NSCLC patients and correlation with response to PD-1/PD-L1 inhibitors

M Janning, F Kobus, A Babayan, H Wikman… - Cancers, 2019 - mdpi.com
Circulating tumor cells (CTCs) hold great potential to answer key questions of how non-
small cell lung cancer (NSCLC) evolves and develops resistance upon anti-PD-1/PD-L1 …

Circulating tumor cells in cancer patients: developments and clinical applications for immunotherapy

X Zhong, H Zhang, Y Zhu, Y Liang, Z Yuan, J Li, J Li… - Molecular cancer, 2020 - Springer
Cancer metastasis is the leading cause of cancer-related death. Circulating tumor cells
(CTCs) are shed into the bloodstream from either primary or metastatic tumors during an …

HPV detection in head and neck squamous cell carcinomas: what is the issue?

JG Augustin, C Lepine, A Morini, A Brunet… - Frontiers in …, 2020 - frontiersin.org
Besides classic tobacco and alcohol risk factors, human papillomavirus (HPV) plays a role in
the development of a subset of head and neck squamous cell carcinomas (HNSCCs), and …

Circulating tumour cells in patients with lung cancer universally indicate poor prognosis

F Jin, L Zhu, J Shao, M Yakoub… - European …, 2022 - Eur Respiratory Soc
Background: In lung cancer, the relevance of various circulating tumour cell (CTC)
subgroups in different lung cancer subtypes is unclear. We performed a comprehensive …

HPV circulating tumoral DNA quantification by droplet‐based digital PCR: a promising predictive and prognostic biomarker for HPV‐associated oropharyngeal …

D Veyer, M Wack, M Mandavit… - … journal of cancer, 2020 - Wiley Online Library
We aimed to determine whether pretherapeutic assessment of HPV circulating tumoral DNA
(HPV ctDNA) by droplet‐based digital PCR (ddPCR) could constitute a predictive and …

Circulating tumor cell PD-L1 expression as biomarker for therapeutic efficacy of immune checkpoint inhibition in NSCLC

V Kloten, R Lampignano, T Krahn, T Schlange - Cells, 2019 - mdpi.com
Over the last decade, the immune checkpoint blockade targeting the programmed death
protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis has improved progression-free …

The role of circulating biomarkers in lung cancer

S Herath, H Sadeghi Rad, P Radfar, R Ladwa… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early
diagnosis is crucial for the management and treatment of this disease. Non-invasive means …

High mobility group box 1 in human cancer

BL Rapoport, HC Steel, AJ Theron, L Heyman, T Smit… - Cells, 2020 - mdpi.com
High mobility group box 1 (HMGB1) is an extremely versatile protein that is located
predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in …