[HTML][HTML] Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

[HTML][HTML] TPM, FPKM, or normalized counts? A comparative study of quantification measures for the analysis of RNA-seq data from the NCI patient-derived models …

Y Zhao, MC Li, MM Konaté, L Chen, B Das… - Journal of translational …, 2021 - Springer
Background In order to correctly decode phenotypic information from RNA-sequencing
(RNA-seq) data, careful selection of the RNA-seq quantification measure is critical for inter …

A cascade nanozyme with amplified sonodynamic therapeutic effects through comodulation of hypoxia and immunosuppression against cancer

N Tao, H Li, L Deng, S Zhao, J Ouyang, M Wen… - ACS …, 2021 - ACS Publications
The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal
to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell …

Sampling the proteome by emerging single-molecule and mass spectrometry methods

MJ MacCoss, JA Alfaro, DA Faivre, CC Wu… - nature methods, 2023 - nature.com
Mammalian cells have about 30,000 times as many protein molecules as mRNA molecules,
which has major implications in the development of proteomics technologies. We discuss …

[HTML][HTML] Gene expression based inference of cancer drug sensitivity

S Chawla, A Rockstroh, M Lehman, E Ratther… - Nature …, 2022 - nature.com
Inter and intra-tumoral heterogeneity are major stumbling blocks in the treatment of cancer
and are responsible for imparting differential drug responses in cancer patients. Recently …

[HTML][HTML] Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome

G Plata, NT Baxter, D Susanti… - Communications …, 2022 - nature.com
Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for
over half a century. Despite mounting concerns about antimicrobial resistance and demand …

[HTML][HTML] Identification and characterization of a novel molecular classification based on disulfidptosis-related genes to predict prognosis and immunotherapy efficacy in …

L Yang, W Zhang, Y Yan - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Background: Disulfidptosis has been discovered as a mechanism of cell death mediating by
SLC7A11. Nonetheless, little is known about the relationship between disulfidptosis-related …

[HTML][HTML] Identification and validation of immunotherapy for four novel clusters of colorectal cancer based on the tumor microenvironment

X Zheng, Y Ma, Y Bai, T Huang, X Lv, J Deng… - Frontiers in …, 2022 - frontiersin.org
The incidence and mortality of colorectal cancer (CRC) are increasing year by year. The
accurate classification of CRC can realize the purpose of personalized and precise …

[HTML][HTML] Roles of m5C RNA modification patterns in biochemical recurrence and tumor microenvironment characterization of prostate adenocarcinoma

Z Xu, S Chen, Y Zhang, R Liu, M Chen - Frontiers in Immunology, 2022 - frontiersin.org
Background Prostate cancer is the second most common cancer with a high risk of
biochemical recurrence (BCR) among men. Recently, 5-methylcytosine (m5C) modification …