Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause
of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number …

Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Simple Summary Prostate cancer (PCa) is the second most frequent type of cancer in men
worldwide. Treatment options for early-stage PCa include external beam radiation therapy …

Engineered three-dimensional (3D) in vitro and ex vivo neural tissues, also known as “mini
brains and spinal cords in a dish,” can be derived from different types of human stem cells …

Purpose Organoids are three-dimensional cultures of stem cells in an environment similar to
the body's extracellular matrix. This is also a novel development in the realm of regenerative …

The prevalency of lung disease has increased worldwide, especially in the aging
population. It is essential to develop novel disease models, that are superior to traditional …

The paradigm of pediatric drug development has been evolving in a “carrot-and-stick”-based
tactic to address population-specific issues. However, the off-label prescription of adult …