Inflammation is an adaptive response of the immune system to noxious insults to maintain
homeostasis and restore functionality. The retina is considered an immune-privileged tissue …

Complement system activation plays an important role in both innate and acquired immunity.
Activation of the complement and the subsequent formation of C5b-9 channels (the …

Osteoarthritis, characterized by the breakdown of articular cartilage in synovial joints, has
long been viewed as the result of'wear and tear'. Although low-grade inflammation is …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …

Traumatic brain injury (TBI) is an important cause of disability and mortality in the western
world. While the initial injury sustained results in damage, it is the subsequent secondary …

Complement is a major component of innate immune system involved in defending against
all the foreign pathogens through complement fragments that participate in opsonization …

Large numbers of neuritic plaques (NP), largely composed of a fibrillar insoluble form of the
β-amyloid peptide (Aβ), are found in the hippocampus and neocortex of Alzheimer's disease …

Complement is a central component of the innate immune system involved in protection
against pathogens. For many years, complement has been known to cause death of targets …

Complement-mediated cell death is caused by C5b-9, the membrane attack complex (MAC)
composed of the five complement proteins C5b, C6, C7, C8, and C9. Assembly of the C5b-9 …

Clinical and experimental studies have suggested that complement may play a role in tumor
cytotoxicity. However, the efficiency of complement-mediated tumor cell lysis is hampered by …