Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as
a local regulator in different pathologies. Adenosine is a ubiquitous nucleoside involved in …

Adenosine receptors (ARs) are a class of G-protein coupled receptors (GPCRs) that are
activated by the endogenous substance adenosine. ARs are classified into 4 subtype …

The photochemical action of arylazo sulfones under visible light irradiation has recently
gained considerable attention for the construction of carbon–carbon and carbon …

Fused pyrimidines scaffolds such as pyrimidopyrimidines, purines and xanthines are
important structural motifs found in various natural products and drug molecules. They are …

Aryl xanthines are selective enzyme inhibitors modified from naturally occurring
methylxanthines. However, the low water solubility of substituted xanthines restricts their …

Xanthine and its derivatives are considered a pharmacologically potential moiety that
manifests immense biological activities. Owing to this much diversity in the biological field …

A set of 8‐arylxanthines was prepared under metal‐free conditions and in aqueous solvents
from arylazo sulfones and caffeine or theophylline. Notably, the process took place by simply …

Xanthine and its derivatives belong to the class of purine alkaloids. They are natural bases
holding nitrogen atoms within the molecular structure, and they have an effective …

Preclinical Research A new series of 1, 3‐dimethylxanthine derivatives bearing 8‐(2‐
nitroaryl) residue was synthesized and evaluated for affinity for recombinant human …

Xanthines and its derivatives are important bronchodilator agents in treating asthma and
bronchitis. In this work, four new 8-aryl xanthine derivatives were synthesized and …