Abstract Interpretation of clinical trials comparing different drug regimens for Parkinson's
disease (PD) is complicated by the different dose intensities used: higher doses of levodopa …

Parkinson's disease is the most common serious movement disorder in the world, affecting
about 1% of adults older than 60 years. The disease is attributed to selective loss of neurons …

Objective To assess the 10-year motor outcome of deep brain stimulation of the subthalamic
nucleus (STN-DBS) in patients with Parkinson disease (PD). Design Patients with PD with …

Deep brain stimulation of the subthalamic nucleus represents the most important innovation
for treatment of advanced Parkinson's disease. Prospective studies have shown that …

Gait disturbances and akinesia are extremely disabling in advanced Parkinson's disease. It
has been suggested that modulation of the activity of the pedunculopontine nucleus (PPN) …

Background: The main advantage of deep brain stimulation (DBS) in the treatment of PD is
that the electrical settings can be adjusted to optimize benefits and minimize adverse effects …

Background Deep brain stimulation of the subthalamic nucleus (STN DBS) is an
increasingly common treatment for Parkinson's disease. Qualitative reviews have concluded …

Background: Long term effects of subthalamic nucleus (STN) stimulation on cognition, mood,
and behaviour are unknown. Objective: This study evaluated the cognitive, mood, and …

Object. Chronic deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a
procedure that is rapidly gaining acceptance for the treatment of symptoms in patients with …

Once it was believed that the subthalamic nucleus (STN) was no more than a relay station
serving as a “gate” for ascending basal ganglia-thalamocortical circuits. Nowadays, the STN …