Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations

RA Purcell, RM Theisen, KB Arnold… - Frontiers in …, 2023 - frontiersin.org
Vaccine efficacy determined within the controlled environment of a clinical trial is usually
substantially greater than real-world vaccine effectiveness. Typically, this results from …

Defining the balance between optimal immunity and immunopathology in influenza virus infection

THO Nguyen, LC Rowntree, BY Chua… - Nature Reviews …, 2024 - nature.com
Influenza A viruses remain a global threat to human health, with continued pandemic
potential. In this Review, we discuss our current understanding of the optimal immune …

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

BY Chua, T Sekiya, M Koutsakos, N Nomura… - PLoS …, 2022 - journals.plos.org
Although antibody-inducing split virus vaccines (SV) are currently the most effective way to
combat seasonal influenza, their efficacy can be modest, especially in immunologically …

Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents

RA Purcell, LC Aurelia, R Esterbauer… - Clinical & …, 2024 - Wiley Online Library
Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may
introduce structural changes that influence recognition by anti‐Ig detection reagents …

Broad spectrum SARS‐CoV‐2‐specific immunity in hospitalized First Nations peoples recovering from COVID‐19

W Zhang, EB Clemens, L Kedzierski… - … and Cell Biology, 2023 - Wiley Online Library
Indigenous peoples globally are at increased risk of COVID‐19‐associated morbidity and
mortality. However, data that describe immune responses to SARS‐CoV‐2 infection in …

Immunization with inactivated whole virus particle influenza virus vaccines induces superior immunity in cynomolgus macaques

B Chua, T Sekiya, M Koutsakos, N Nomura… - 2022 - researchsquare.com
Influenza viruses circulate globally, causing seasonal influenza outbreaks. Although
antibody-inducing vaccines are the most effective way to combat seasonal infections, current …