Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Enoyl acyl carrier protein reductase (InhA) is a key enzyme involved in fatty acid synthesis
mainly mycolic acid biosynthesis that is a part of NADH dependent acyl carrier protein …

The article explores the polypharmacological profiling of 4-((5-(decylthio)-4-methyl-4H-1, 2,
4-triazole-3-yl) methyl) morpholine as a potential antimicrobial agent. The study utilized …

By palladium catalysis, the C− H bond functionalization of O-phenylcarbamates with simple
arenes has been achieved using sodium persulfate (Na2S2O8), an inexpensive, easy-to …

The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis
around the world, including in industrialized nations, poses a great threat to human health …

Docking scoring functions are notoriously weak predictors of binding affinity. They typically
assign a common set of weights to the individual energy terms that contribute to the overall …

Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …

Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

The modern age of drug discovery, which had been slowly gathering momentum during the
early part of the twentieth century, exploded into life in the 1940s with the isolation of …

InhA, the enoyl-ACP reductase in Mycobacterium tuberculosis is an attractive target for the
development of novel drugs against tuberculosis, a disease that kills more than two million …