Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
[HTML][HTML] Representing structures of the multiple conformational states of proteins
Biomolecules exhibit dynamic behavior that single-state models of their structures cannot
fully capture. We review some recent advances for investigating multiple conformations of …
fully capture. We review some recent advances for investigating multiple conformations of …
A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
W Pang, Y Lu, YB Zhao, F Shen, CF Fan, Q Wang… - Cell Research, 2022 - nature.com
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike
(S) protein are weakening the efficacy of the current vaccines and antibody therapeutics …
(S) protein are weakening the efficacy of the current vaccines and antibody therapeutics …
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …
SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype
Since the emergence of the Omicron variants at the end of 2021, they quickly became the
dominant variants globally. The Omicron variants may be more easily transmitted compared …
dominant variants globally. The Omicron variants may be more easily transmitted compared …
SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade
Accumulating evidence indicates a potential role for bacterial lipopolysaccharide (LPS) in
the overactivation of the immune response during SARS-CoV-2 infection. LPS is recognized …
the overactivation of the immune response during SARS-CoV-2 infection. LPS is recognized …
Toxin-like peptides from the bacterial cultures derived from gut microbiome infected by SARS-CoV-2—new data for a possible role in the long COVID pattern
C Brogna, S Cristoni, B Brogna, DR Bisaccia, G Marino… - Biomedicines, 2022 - mdpi.com
It has been 3 years since the beginning of the SARS-CoV-2 outbreak, however it is as yet
little known how to care for the acute COVID-19 and long COVID patients. COVID-19 clinical …
little known how to care for the acute COVID-19 and long COVID patients. COVID-19 clinical …
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody
A Zibat, X Zhang, A Dickmanns, KM Stegmann… - Iscience, 2023 - cell.com
Summary N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is
incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an" …
incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an" …
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein
The COVID-19 pandemic has prompted a rapid response in vaccine and drug development.
Herein, we modeled a complete membrane-embedded SARS-CoV-2 spike glycoprotein and …
Herein, we modeled a complete membrane-embedded SARS-CoV-2 spike glycoprotein and …
Exploring the pH dependence of the SARS‐CoV‐2 complete fusion domain and the role of its unique structural features
D Birtles, AE Oh, J Lee - Protein Science, 2022 - Wiley Online Library
SARS‐CoV‐2 may enter target cells through the process of membrane fusion at either the
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …
plasma (~ pH 7.4–7.0) or endosomal (~ pH 6.5–5.0) membrane in order to deliver its genetic …